Lung Cancer Cell Lines As Tools For Biomedical Discovery And Research

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Lung cancer cell lines as tools for biomedical discovery and research.

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Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. Gazdar af girard l lockwood ww lam wl minna jd 2010 lung cancer cell lines as tools for biomedical discovery and research.

Lung cancer cell lines as tools for biomedical discovery and research. Activity and safety of azd3759 in egfr mutant non small cell lung cancer with cns metastases bloom. But smoking is still responsible for most lung cancer deaths. J natl cancer inst 102.

Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Research into new immunotherapies and new ways to use these treatments is ongoing. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those.

A phase 1 open label dose escalation and dose expansion study. Lung cancer and normal cell lines atcc no. The goal of the consortium is to accelerate progress in small cell lung cancer research through information exchange data sharing and analysis and face to face. The pd 1 pathway may be very important in the immune system s ability to control cancer growth.

A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those for other common epithelial cancers. Lee js ahn js et al.